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Free radicals and antioxidants antiaging properties, oxidative damage

Severe caloric restriction has been found to reduce reactive oxidative species and to increase the life-span of rodents, possibly by promoting mitohormesis. Studies have shown that both calorie restriction and reduced meal frequency or intermittent fasting can suppress the development of various diseases and can increase life span in rodents by 30-40% by mechanisms involving stress resistance and reduced oxidative damage[3].

Free radicals damage explains cell death in number of circumstances. However, free radicals are naturally produced by some systems within the body and have beneficial effects that cannot be overlooked. The immune system is the main body system that utilizes free radicals. Following recommendations may help with protection against free radical damage:

5-8 servings of vegetables everyday
Allocate 10-15 % of your daily intake to nuts
Reduce the stress by: Regular exercise, relaxation techniques such as Yoga and ThiChi
Avoid overexposure to sun
Avoid smoking
Green tea and other teas are good examples of antioxidants
Liver and brewer's yeast, anchovies, artichoke are good sources of alpha lipoic acid
Acupuncture, an ancient science that can help with decreasing
amount of epinephrine, norepinephrine around the cell and lessen
oxidative stress

Long term benefits of taking high dose of vitamins is not proven yet. Some studies suggest that the addition of antioxidants can lead to a decrease of normal biological response to free radicals and lead to a more sensitive environment to oxidation. it seems supplying body with antioxidants through a balanced diet rich in fruits, green leafy vegetables, nuts and whole grains provides a more natural way of protection against free radicals.

References:

1. ^ Jeremy M. Van Rammsdonk, Siegfried Hekimi. "Deletion of the Mitochondrial Superoxide Dismutase sod-2 Extends Lifespan in Caenorhabditis elegans".http://www.plosgenetics.org/article/info%3Adoi%2F10.1371%2Fjournal.pgen.1000361

2. ^ a b Schulz TJ, Zarse K, Voigt A, Urban N, Birringer M, Ristow M (2007). "Glucose restriction extends Caenorhabditis elegans life span by inducing mitochondrial respiration and increasing oxidative stress". Cell Metabolism 6 (4): 280–93.http://www.cellmetabolism.org/content/article/abstract?uid=PIIS1550413107002562

3. ^ {http://www.ncbi.nlm.nih.gov/pubmed/16446459 Calorie restriction induces mitochondrial biogenesis and bioenergetic efficiency

 

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